Physician Scientist - Therapeutic Area Genetics (Immune, Respiratory, and Infectious Disease)
Regeneron Genetics Center
Location: Tarrytown, New York
Type: Full Time
Preferred Education: Doctorate
Years of Experience:
5 - 10
Internal Number: R2271
We are looking for a Physician Scientist to join our Immune, Respiratory and Infectious Disease Therapeutic Area Genetics (TAG) team. The position will be responsible for the translation of human genetic evidence into therapeutically-actionable insights in Immune, Respiratory and Infectious Diseases.
In this role, a typical day might include the following:
•Design and contribute to large-scale genetic association studies and refined analysis that will enable interpretation of human genetic analyses. •Apply human genetics to target discovery, select indications for drug programs and identify subgroups of patients who are more likely to respond to treatment through genetic analyses. •Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other required staff to design, execute, and interpret genetics studies related to immunologic, infectious and respirologic diseases.
This job might be for you if you:
•Bring innovative thinking to large-scale genetic studies and analysis. •Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron. •Are a motivated teammate with a desire to pursue genetic discovery in a fast-paced multi-disciplinary environment.
To be considered for this role, you must have a PhD and/or MD with strong background in and knowledge of human genetics or genetic epidemiology. Training and experience in translational human genetics, genetic epidemiology (or related disciplines) and strong quantitative skills. Proven ability to design and lead human genetics studies delivering medically-relevant findings. Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative research questions. Familiarity with clinical genetics concepts and genetic models of disease. Experience leading complex human genetics research endeavors. Knowledge of different study designs and analyses including GWAS, exome or genome sequencing in cohort, case-control or family-based studies. Ability to integrate different data resources to translate initial findings. Experience with the use of genetics in combination with other “omics” technologies (eg. metabolomics, proteomics, RNA-seq). Familiarity with the applications of statistical genetics to gain medically-actionable insights including polygenic risk scores, quantitative traits analyses and Mendelian randomization. Familiarity with command line interface, programming languages and statistical software (eg. Python, R, STATA).
The Regeneron Genetics Center® (RGC) is a uniquely integrated research initiative that seeks to improve patient care by using genomic approaches to speed drug discovery and development. Our collaborations are key to our success. We work with a large network of collaborator institutions to gather and analyze data, exchange expert perspectives and search for discoveries to transform patient care. Our innovative technologies enable us to quickly and effectively sequence exomes and analyze data. Through human ingenuity, machine learning, artificial intelligence and more, we maintain one of the biggest genome centers in the world. By tapping into our vast data resource, we are able to make discoveries about human health and genetics that accelerate our drug development process. Our ultimate goal is to make a positive impact on patients – both in the short-term through results returned via collaborators, and in the longer-term by informing research into new medicines. As we identify interesting findings from our research, we share it with other teams at Regeneron to accelerate our drug discovery and development process. Sometimes this data validates what we've already seen in other ongo...ing research, and other times it informs new avenues of research for potential therapies. Either way, our genetics research makes us more nimble and targeted when it comes to pursuing new medicines for people with serious diseases.