Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to produce clinical drug candidates for the Pfizer pipeline. This position will work within the Target Sciences (TS) group, which has collective expertise in human genetics and functional genomics, computational biology and data management, and target validation biology, and an overall remit to discover and validate hypotheses for novel, emerging science drug targets. The primary responsibility of this position is to design, develop, execute and interpret computational experiments, utilizing relevant internal and external biological data sources, to advance drug-discovery targets within Pfizer’s Centers for Therapeutic Innovation (CTI) and emerging science target hypotheses emanating from TS internal efforts and from Pfizer’s industrial-academic partnerships. To this end, the position will be responsible for the development of bespoke analytical and visualization tools, supporting pipelines and workflows, and data integration environments; and will work closely with the emerging science geneticists, biologists and functional genomics scientists in TS and with CTI project leads. This position requires a deep expertise in bioinformatics, including computational workflows and pipelines, tools and methodologies, and data integration techniques. The position will benefit from additional expertise in computational biology, incl. some knowledge of disease pathophysiology in at least one disease area of interest to Pfizer R&D; some experience in progressing target hypotheses and projects through computational approaches and insights in a pharmaceutical Research setting; and an ability to achieve impact through focus within a wide swath of potential project and technology opportunities.
Engage with TS and CTI project teams to advance critical target validation objectives through the development and application of computational approaches, and to champion innovative proposals that extend such approaches.
Develop and apply bespoke computational algorithms and workflows to support project-specific analytical and visualization tasks required for decision making in Emerging Science projects.
Deliver computational analyses of high-dimensional datasets, e.g., RNA-Seq, NGS, proteomics or metabolomics, from model systems, disease systems, and molecular profiling databases to understand the interplay between disease biology, genes and mechanisms that enable progression of emerging science target hypotheses and discovery projects.
Integrate multiple levels of biological information to inform protein-disease networks in the context of emerging science drug discovery.
Provide hypotheses and insights based on complex, multi-dimensional data analyses to inform and aid in design of biological validation studies to be conducted by the Emerging Science genomics and biology groups, CTI project teams and/or RU project teams for functional validation (e.g., siRNA, CRISPR/Cas9) of emerging science target hypotheses and projects.
In partnership with RU computational biologists, the Computational Biology platform group, and non-clinical biostatistics, identify novel data sources, computational methods, and external collaborations that will grow capabilities in computational target validation.
Support key internal/external collaborations that secure access to innovative computational methodologies and/or relevant datasets to advance our ability to understand disease pathophysiology from large-scale molecular and phenotypic data.
Ph.D. in Computational Biology, Biological Sciences, Bioinformatics, Computer Science, Applied Mathematics or other natural science required; 2+ years relevant experience applying quantitative approaches to solving biological problems, preferably in a pharmaceutical, biotech or comparable context.
Background in human biology/medicine, with some knowledge of disease pathophysiology in at least one disease area of interest to Pfizer R&D, e.g., Immunology & Inflammation, Oncology, Rare Disease, and Internal Medicine.
Curiosity about biological and pathological processes and mechanisms.
Excellent technical proficiency in multiple programming, scripting, querying or statistical analysis languages, incl. R, Python, PERL and SQL.
Demonstrated experience in the design, development, execution and interpretation of data generation and computational experiments on in vivo and in vitro biological data, especially RNA-Seq or other NGS data.
Demonstrated experience in delivering insights and hypotheses from complex multi-dimensional biological data in a biomedical context.
Demonstrated experience in applying computational approaches to deliver insights and hypotheses, e.g., multi-variate, Bayesian and machine learning approaches.
Pharmaceutically relevant experience or formal training in computational biology, bioinformatics, computer science or medicine.
Demonstrated ability for sound experimental design of in-silico experimentation/workflows required, in addition to ability to effectively interface with Emerging Science / CTI biologists to communicate/discuss results, ideas, and follow-up experiments.
Working knowledge of relevant public and proprietary databases, methods and tools.
Excellent communication skills (oral and written) as demonstrated by publications and presentations.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional travel will be required to non-Cambridge Pfizer sites and to scientific meetings.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Eligible for Relocation Package
Eligible for Employee Referral Bonus
Employer will assist with relocation costs.
Internal Number: 4727134
About Pfizer, Inc
Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. We make medicines and vaccines that help people when they are sick and prevent them from getting sick in the first place, as well as some of the world’s best-known consumer healthcare brands. Every day, our colleagues work in developed and emerging markets to treat, cure and eradicate life-threatening conditions and challenge some of the most feared diseases of our time. Pfizer also collaborates with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. To learn more, visit www.pfizer.com. For additional information on our guidelines, please visit http://www.pfizer.com/community-guidelines